Addition of cranberry to proton pump inhibitor-based triple therapy for <i>Helicobacter pylori</i> eradication :Mohammadreza Seyyedmajidi, Anahita Ahmadi, Shahin Hajiebrahimi, Seyedali Seyedmajidi, Majid Rajabikashani, Mona Firoozabadi, Jamshid Vafaeimanesh, Journal of Research in Pharmacy Practice

ORIGINAL ARTICLE
Year : 2016 | Volume : 5 | Issue : 4 | Page : 248--251

Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication

Mohammadreza Seyyedmajidi¹, Anahita Ahmadi¹, Shahin Hajiebrahimi¹, Seyedali Seyedmajidi¹, Majid Rajabikashani¹, Mona Firoozabadi¹, Jamshid Vafaeimanesh²
¹ Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran
² Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom; Gastrointestinal and Liver Diseases Research Center, University of Medical Sciences, Tehran, Iran

Correspondence Address:
Jamshid Vafaeimanesh
Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran
Iran

Objective: Proton pump inhibitor-based triple therapy with two antibiotics for Helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including H. pylori. The aim of this study was to assess the effect of cranberry on H. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD). Methods: In this study, H. pylori-positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A ¹³C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment. Findings: Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent ¹³C-urea breath testing. H. pylori eradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) (P = 0.042). Conclusion: The addition of cranberry to LCA triple therapy for H. pylori has a higher rate of eradication than the standard regimen alone (up to 89% and significant).

How to cite this article:
Seyyedmajidi M, Ahmadi A, Hajiebrahimi S, Seyedmajidi S, Rajabikashani M, Firoozabadi M, Vafaeimanesh J. Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication.J Res Pharm Pract 2016;5:248-251

How to cite this URL:
Seyyedmajidi M, Ahmadi A, Hajiebrahimi S, Seyedmajidi S, Rajabikashani M, Firoozabadi M, Vafaeimanesh J. Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication. J Res Pharm Pract [serial online] 2016 [cited 2023 Mar 27 ];5:248-251
Available from: https://www.jrpp.net/article.asp?issn=2319-9644;year=2016;volume=5;issue=4;spage=248;epage=251;aulast=Seyyedmajidi;type=0