| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 5
| Issue : 4 | Page : 248-251 |
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Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication
Mohammadreza Seyyedmajidi1, Anahita Ahmadi1, Shahin Hajiebrahimi1, Seyedali Seyedmajidi1, Majid Rajabikashani1, Mona Firoozabadi1, Jamshid Vafaeimanesh2
1 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran
2 Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom; Gastrointestinal and Liver Diseases Research Center, University of Medical Sciences, Tehran, Iran
Correspondence Address:
Jamshid Vafaeimanesh
Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2279-042X.192462
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Objective: Proton pump inhibitor-based triple therapy with two antibiotics for Helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including H. pylori. The aim of this study was to assess the effect of cranberry on H. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD).
Methods: In this study, H. pylori-positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A 13C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment.
Findings: Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent 13C-urea breath testing. H. pylori eradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) (P = 0.042).
Conclusion: The addition of cranberry to LCA triple therapy for H. pylori has a higher rate of eradication than the standard regimen alone (up to 89% and significant). |
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